The "vaccine incident" that occurred last year set off alarm bells across China's vaccine industry. Upgrading and innovative development within the vaccine sector have become an urgent necessity.

As an enterprise focused on innovation-driven vaccine research and development, Minhai biotechnology takes up vital responsibilities with originality and ingenuity. In January 2019, Minhai biotechnology's new project for inactivated poliomyelitis vaccine and human diploid cell rabies vaccine was completed.

The new project is constructed according to updated GMP standards and adopts the one-piece corner panel from Cnsterilezoom. The one-piece corner panel featuring patented technology has become a highlight of the project construction. Technical innovation achieves a new height of cleanroom cleanliness.

Standard: Higher than multinational corporations

As the core independent innovation-oriented enterprise of the "vaccine national team", Minhai biotechnology holds the "863" project of many countries. Minhai ranks at the top in domestic R&D and production of the 13-valent pneumococcal polysaccharide conjugate vaccine.

Vaccines are vital to the national economy and people's livelihood. Vaccine enterprises must maintain high standards across raw materials, production processes, and inspection. Located in Beijing Daxing district and covering an area of 24525 ㎡, this new project is a modern production base for polio vaccine and rabies vaccine. The production lines were designed by Dutch and German experts respectively, procuring the most advanced international equipment. The facility not only meets the new GMP standards, but exceeds multinational standards.

The polio vaccine production line introduced a complete set of unique wsIPV production technology and quality management systems from Intravacc in the Netherlands.

Products will be sourced by the WHO, with the entire process strongly supported by the Bill & Melinda Gates Foundation. The rabies vaccine production line will also utilize a complete set of internationally advanced Pasteur human diploid rabies vaccine technology.

Solution: Victories of structural innovation

The implementation of high technical standards is inseparable from the most stringent cleanroom construction. Customized system solutions for the new Minhai biotechnology project are provided by Cnsterilezoom. The clean room panels cover an area of more than 23,000 square meters overall, of which the application area of the body corner plate reaches 1500 square meters, greatly improving cleanliness.

(1) Eliminate the structural dead angle

The traditional clean room corner is formed by the joint of the clean plate and the aluminum profile, which easily leads to dust accumulation at the contact positions and makes cleaning and disinfection difficult. This is a "structural dead angle" in traditional enclosure systems. Furthermore, GMP guidelines state,

The inner surface (wall, floor, and ceiling) of the clean area shall be smooth and free from cracks, with tight joints and no particle shedding, preventing dust accumulation and facilitating effective cleaning and disinfection when necessary.

The core solution of Cnsterilezoom cleanroom system with patented technology—integrated corner panels—perfectly resolves the traditional dust accumulation at the contact position between aluminum profiles and clean panels. Transforming clean panels into whole corner panels ensures smooth corners with seamless transitions, a tighter interface, and zero leakage.

(2) Eliminate the thermal bridge phenomenon

Thermal bridging not only shortens the service life of building materials, but also impairs the thermal insulation performance of clean panels, resulting in increased condensation dew and rising operational costs. The thermal bridge phenomenon typically occurs at the butt seams of the panels.

Cleanroom panels: the ideal choice to challenge performance limits

The main body clean panels adopted in the new project of Minhai biology, whose core material is double gypsum rock wool panel with superior flatness, high toughness, corrosion resistance, and contamination resistance, represent the ideal choice for cleanroom environments.

Double-layer plaster panels use products from Saint-Gobain, the renowned building materials magnate, offering moisture-proof, stable, and high-grade performance. Non-wedge panels deliver superior flatness, combining gypsum and high quality marine rock wool panel forms a seamless structure, significantly improving surface flatness, structural strength, and fire performance.

The automated production line is independently designed and developed by Cnsterilezoom steel products, which is the first of its kind globally and holds national patents. The precision, flatness, and aesthetics of clean panels have been greatly improved, truly achieving "technology makes every purification panel the same".

Adapting to the challenges of stringent purification engineering, we are committed to growing alongside customers and collaborating with enterprises to establish a clean, intelligent, and modern industrial system.